Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase
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Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.
Use of improvised explosive devices has significantly increased the incidence of traumatic brain injury (TBI) and associated neuropsychiatric deficits in the recent wars in Iraq and Afghanistan. Acute deleterious effects of single and repeated blast exposure can lead to long-term neurobiological effects and neuropsychiatric deficits. Using in vitro and in vivo shock tube models of blast-induced...
متن کاملEffects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats
Excessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this en...
متن کاملThe enzyme-enzyme complex of transaminase and glutamate dehydrogenase.
Glutamate dehydrogenase decreases the distribution COefficient of glutamate oxalacetate transaminase in Sephadex G-ZOO. This is consistent with previous results which suggested that a complex is formed between these two enzymes. These gel filtration as well as kinetic experiments suggest that transaminase can react with monomeric but not polymer forms of glutamate dehydrogenase. When the levels...
متن کاملDffluoro-oxaloacetate with Aspartate Transaminase
Difluoro-oxaloacetate interacts with the aldimine form of aspartate transaminase to give a complex, the dissociation constant ofwhich has been determined spectrophotometrically and by 19F n.m.r. (nuclear magnetic resonance). The 19F n.m.r. line-width-pH and chemical-shift-pH profiles of difluoro-oxaloacetate in the presence of the aldimine form of the enzyme both show inflexion points in the pH...
متن کاملThe intracellular distribution, latency and electrophoretic mobility of L-glutamate-oxaloacetate transaminase from rat liver.
Richardson, E. M., Bulaschenko, H. & Dohan, F. C. (1958). J. clin. Endocrin. 18, 666. Richardson, E. M., Touchstone, J. C., Dohan, F. C., Bulaschenko, H., Landolt, I. & Applin, W. (1955). J. clin. Invest. 34, 285. Rimini, E. (1901). Gazz. chim. ital. 31, II, 84. Romani, J. D. (1956a). C.R. Soc. Biol., Paris, 150, 644. Romani, J. D. (1956b). C.R. Soc. Biol., Paris, 150, 887. Romani, J. D. & Able...
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ژورنال
عنوان ژورنال: Integrative Food, Nutrition and Metabolism
سال: 2018
ISSN: 2056-8339
DOI: 10.15761/ifnm.1000228